(S)-1-[3-(Trifluoromethyl)phenyl]ethylamine

(S)-1-[3-(Trifluoromethyl)phenyl]ethylamine - Names and Identifiers

Name	(S)-1-[3-(Trifluoromethyl)phenyl]ethylamine
Synonyms	S-MTF-PEM 1-[3-(trifluoromethyl)phenyl]ethanol (S)-1-[3-(Trifluoromethyl)phenyl]ethylamine (S)-1-[3-(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE (S)-1-(3-(TRIFLUOROMETHYL)PHENYL)ETHANAMINE (1R)-1-[3-(trifluoromethyl)phenyl]ethanamine (1S)-1-[3-(Trifluoromethyl)phenyl]ethylamine (1S)-1-[3-(trifluoromethyl)phenyl]ethanamine (S)-1-[3-(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE-HCl Benzenemethanamine, α-methyl-3-(trifluoromethyl)-, (αS)- (S)-1-[3-(TrifluoroMethyl)phenyl]ethylaMine hydrochloride (S)-1-[3-(Trifluoromethyl)phenyl]ethylamine (S)-α-(m-(trifluoromethyl)phenyl)ethylamine
CAS	127852-21-5
InChI	InChI=1/C9H10F3N/c1-6(13)7-3-2-4-8(5-7)9(10,11)12/h2-6H,13H2,1H3/t6-/m0/s1

(S)-1-[3-(Trifluoromethyl)phenyl]ethylamine - Physico-chemical Properties

Molecular Formula	C9H10F3N
Molar Mass	189.18
Density	1.180±0.06 g/cm3(Predicted)
Boling Point	184.1±35.0 °C(Predicted)
Flash Point	72.2°C
Vapor Presure	0.746mmHg at 25°C
pKa	8.72±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.465

(S)-1-[3-(Trifluoromethyl)phenyl]ethylamine - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36 - Irritating to the eyes
Safety Description	26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Hazard Note	Irritant

(S)-1-[3-(Trifluoromethyl)phenyl]ethylamine - Introduction

(S)-1-[3-(trifluoromethyl) phenyl] ethylamine is an organic compound with the chemical formula C9H10F3N. It has the following properties:

1. Appearance:(S)-1-[3-(trifluoromethyl) phenyl] ethylamine is a colorless to pale yellow liquid.

2. Solubility: It can be dissolved in many organic solvents, such as ethanol, dimethyl sulfoxide and dimethylformamide.

3. Chemical properties: It is a weak base that can react with acid to generate salt. In addition, it can be chemically changed by reactions such as electrophilic substitution reaction, nucleophilic substitution reaction and carbonyl reduction.

(S)-1-[3-(trifluoromethyl) phenyl] ethylamine has a wide range of applications in the field of medicine, mainly used as chiral separation reagents, organic synthesis intermediates and drug ligands. It has important applications in the synthesis of anticancer drugs, neuromodulators and chemical sensors.

It can be prepared by the following methods:

A Suzuki coupling reaction was performed using (S)-acetylacetone and 3-(trifluoromethyl) phenylboronic acid. Specific steps are as follows:
Step 1: (S)-acetylacetone and 3-(trifluoromethyl) phenylboronic acid are added to a reactor, and an appropriate amount of palladium (II) alkoxide and a base catalyst are added.
Step 2: Under a nitrogen atmosphere, the reaction is carried out at an appropriate temperature and stirred for a period of time.
Step 3: The reaction mixture is filtered, then acidified with an acidic aqueous solution, and extracted and purified.
Step 4: Finally, the pure product was obtained by vacuum distillation.

For safety information, (S)-1-[3-(trifluoromethyl) phenyl] ethylamine should follow general laboratory procedures. It can cause irritation and damage to the eyes, skin and respiratory tract. Care should be taken to avoid contact and inhalation during use, and appropriate protective equipment should be worn during operation, such as chemical laser glasses, protective gloves and protective masks.

Last Update：2024-04-09 21:00:56